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Article

Effects of Transmission Bottlenecks on the Diversity of Influenza A Virus.

Genetics - 1 Nov 2018

Sigal Daniel, Reid Jennifer N S, Wahl Lindi M

Abstract excerpt

We investigate the fate of de novo mutations that occur during the in-host replication of a pathogenic virus, predicting the probability that such mutations are passed on during disease transmission to a new host. Using influenza A virus as a model organism, we develop a life-history model of the within-host dynamics of the infection, deriving a multitype branching process with a coupled deterministic model to...

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Identifiers

PMID: 30181193
DOI: 10.1534/genetics.118.301510
PMCID: PMC6218237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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