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Article

Rare variants and biological pathways identified in treatment-refractory depression.

Journal of neuroscience research - 1 Jul 2020

McClain Lora Lee, Shaw Patricia, Sabol Roisin, Chedia Anna Maria, Segretti Anna Maria, Rengasamy Manivel, Finegold David N, Pan Lisa, Peters David Gerard

Abstract excerpt

Individuals diagnosed with major depressive disorder not responding to at least two adequate treatments are defined as treatment-refractory major depressive disorder (TR-MDD). Some TR-MDD patients have altered metabolic phenotypes that may be pharmacologically reversed. The characterization of these phenotypes and their underlying etiologies is paramount, particularly their genetic components. In this study,...

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Source

Identifiers

PMID: 32128872
DOI: 10.1002/jnr.24609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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