Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance.

doi:10.1007/s00406-017-0766-1

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Article

Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance.

European archives of psychiatry and clinical neuroscience - 1 Dec 2017

Fabbri Chiara, Crisafulli Concetta, Calati Raffaella, Albani Diego, Forloni Gianluigi, Calabrò Marco, Martines Rosalba, Kasper Siegfried, Zohar Joseph, Juven-Wetzler Alzbeta, Souery Daniel, Montgomery Stuart, Mendlewicz Julien, Serretti Alessandro

Abstract excerpt

Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous findings in an independent sample with treatment-resistant depression (TRD), and (2) to perform a pathway analysis to investigate the possible molecular mechanisms involved. 220 patients with major...

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Identifiers

PMID: 28260126
DOI: 10.1007/s00406-017-0766-1

Genes

CHL1
TRD
MAPK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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