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Article

Structure specific recognition of telomeric repeats containing RNA by the RGG-box of hnRNPA1

21 Feb 2020

Abstract excerpt

The telomere repeats containing RNA (TERRA) is transcribed from the C-rich strand of telomere DNA and comprises of UUAGGG nucleotides repeats in humans. The TERRA RNA repeats can exist in single stranded, RNA-DNA hybrid and G-quadruplex forms in the cell. Interaction of TERRA RNA with hnRNPA1 has been proposed to play critical roles in maintenance of telomere DNA. hnRNPA1 contains an N-terminal UP1 domain...

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Share to RNA and protein synthesis mechanisms
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Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32128583
DOI: 10.1093/nar/gkaa134

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