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Article

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.

Nucleic acids research - 1 Apr 2014

Kuo Pan-Hsien, Chiang Chien-Hao, Wang Yi-Ting, Doudeva Lyudmila G, Yuan Hanna S

Abstract excerpt

TDP-43 is an important pathological protein that aggregates in the diseased neuronal cells and is linked to various neurodegenerative disorders. In normal cells, TDP-43 is primarily an RNA-binding protein; however, how the dimeric TDP-43 binds RNA via its two RNA recognition motifs, RRM1 and RRM2...

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Source

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Identifiers

PMID: 24464995
DOI: 10.1093/nar/gkt1407
PMCID: PMC3985631

Genes

RRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24464995-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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