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Article

hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro

1 Jun 2001

Abstract excerpt

The hnRNP A1 protein and a shortened derivative (UP1) promote telomere elongation in mammalian cells. In support of a direct role for A1 in telomere biogenesis, we have shown that the recombinant UP1 protein binds to telomeric DNA sequences in vitro, and pulls down telomerase activity from a cell extract. Here we show that A1/UP1 can interact directly with the RNA component of human telomerase (hTR). A portion of...

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PMID: 11376145
DOI: 10.1093/nar/29.11.2268

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