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Article

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast.

EMBO reports - 1 Jun 2011

Iglesias Nahid, Redon Sophie, Pfeiffer Verena, Dees Martina, Lingner Joachim, Luke Brian

Abstract excerpt

Telomeric repeat-containing RNA (TERRA) has been implicated in the control of heterochromatin and telomerase. We demonstrate that yeast TERRA is regulated by telomere-binding proteins in a chromosome-end-specific manner that is dependent on subtelomeric repetitive DNA elements. At telomeres that contain only X-elements, the Rap1 carboxy-terminal domain recruits the Sir2/3/4 and Rif1/2 complexes to repress...

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Share to Chromosomes, Fungal
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Repetitive Sequences, Nucleic Acid

Share to RNA, Untranslated

Share to Shelterin Complex

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Share to Telomere-Binding Proteins

Source

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Identifiers

PMID: 21525956
DOI: 10.1038/embor.2011.73
PMCID: PMC3128280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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