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Article

Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1.

Science advances - 1 Feb 2020

Xhani Suela, Lee Sangchoon, Kim Hye Mi, Wang Siming, Esaki Shingo, Ha Van L T, Khanezarrin Mahtab, Fernandez Giselle L, Albrecht Amanda V, Aramini James M, Germann Markus W, Poon Gregory M K

Abstract excerpt

Transcription factors comprise a major reservoir of conformational disorder in the eukaryotic proteome. The hematopoietic master regulator PU.1 presents a well-defined model of the most common configuration of intrinsically disordered regions (IDRs) in transcription factors. We report that the structured DNA binding domain (DBD) of PU.1 regulates gene expression via antagonistic dimeric states that are...

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Identifiers

PMID: 32128405
DOI: 10.1126/sciadv.aay3178
PMCID: PMC7034988

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