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Article

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Biochimica et biophysica acta. General subjects - 1 Jun 2018

Santofimia-Castaño Patricia, Rizzuti Bruno, Abián Olga, Velázquez-Campoy Adrián, Iovanna Juan L, Neira José L

Abstract excerpt

BACKGROUND: NUPR1 is a multifunctional intrinsically disordered protein (IDP) involved, among other functions, in chromatin remodelling, and development of pancreatic ductal adenocarcinoma (PDAC). It interacts with several biomolecules through hydrophobic patches around residues Ala33 and Thr68. The drug trifluoperazine (TFP), which hampers PDAC development in xenografted mice, also binds to those regions....

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Source

Identifiers

PMID: 29530795
DOI: 10.1016/j.bbagen.2018.03.009

Genes

NUPR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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