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Article

Molecular basis of facilitated target search and sequence discrimination of TALE homeodomain transcription factor Meis1.

Nature communications - 14 Aug 2024

Choi Seo-Ree, Lee Juyong, Seo Yeo-Jin, Jin Ho-Seong, Ahn Hye-Bin, Go Youyeon, Kim Nak-Kyoon, Ryu Kyoung-Seok, Lee Joon-Hwa

Abstract excerpt

Transcription factors specifically bind to their consensus sequence motifs and regulate transcription efficiency. Transcription factors are also able to non-specifically contact the phosphate backbone of DNA through electrostatic interaction. The homeodomain of Meis1 TALE human transcription factor (Meis1-HD) recognizes its target DNA sequences via two DNA contact regions, the L1-α1 region and the α3 helix...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39143123
DOI: 10.1038/s41467-024-51297-7
PMCID: PMC11325038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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