Article
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2014
Rogers Joseph M, Oleinikovas Vladimiras, Shammas Sarah L, Wong Chi T, De Sancho David, Baker Christopher M, Clarke Jane
Abstract excerpt
Protein-protein interactions are at the heart of regulatory and signaling processes in the cell. In many interactions, one or both proteins are disordered before association. However, this disorder in the unbound state does not prevent many of these proteins folding to a well-defined, ordered structure in the bound state. Here we examine a typical system, where a small disordered protein (PUMA, p53 upregulated...
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