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Article

Multiple DNA-binding modes for the ETS family transcription factor PU.1.

The Journal of biological chemistry - 29 Sept 2017

Esaki Shingo, Evich Marina G, Erlitzki Noa, Germann Markus W, Poon Gregory M K

Abstract excerpt

The eponymous DNA-binding domain of ETS (E26 transformation-specific) transcription factors binds a single sequence-specific site as a monomer over a single helical turn. Following our previous observation by titration calorimetry that the ETS member PU.1 dimerizes sequentially at a single sequence-specific DNA-binding site to form a 2:1 complex, we have carried out an extensive spectroscopic and biochemical...

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Identifiers

PMID: 28790174
DOI: 10.1074/jbc.M117.798207
PMCID: PMC5625037

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