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Article

Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15.

Cell death and differentiation - 1 Aug 2020

Kong EunBin, Kim Hag Dong, Kim Joon

Abstract excerpt

Autophagy is a cellular catabolic process that maintains intracellular homeostasis using lysosomal degradation systems. We demonstrate that inhibiting autophagy by depleting essential autophagy elongation proteins, Atg5 or Atg7, induces ISG15 expression through STING-mediated cytosolic dsDNA response. Genome stability is impaired in ATG5- or ATG7-depleted cells, and thus, double-strand breakages of DNA increase...

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Identifiers

PMID: 32127658
DOI: 10.1038/s41418-020-0519-y
PMCID: PMC7370226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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