Article
Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.
Blood advances - 10 Mar 2020
Shrestha Raksha, Sakata-Yanagimoto Mamiko, Maie Koichiro, Oshima Motohiko, Ishihara Masatomo, Suehara Yasuhito, Fukumoto Kota, Nakajima-Takagi Yaeko, Matsui Hirotaka, Kato Takayasu, Muto Hideharu, Sakamoto Tatsuhiro, Kusakabe Manabu, Nannya Yasuhito, Makishima Hideki, Ueno Hiroo, Saiki Ryunosuke, Ogawa Seishi, Chiba Kenichi, Shiraishi Yuichi, Miyano Satoru, Mouly Enguerran, Bernard Olivier A, Inaba Toshiya, Koseki Haruhiko, Iwama Atsushi, Chiba Shigeru
Abstract excerpt
Loss-of-function mutations in ten-eleven translocation-2 (TET2) are recurrent events in acute myeloid leukemia (AML) as well as in preleukemic hematopoietic stem cells (HSCs) of age-related clonal hematopoiesis. TET3 mutations are infrequent in AML, but the level of TET3 expression in HSCs has been found to decline with age. We examined the impact of gradual decrease of TET function in AML development by...
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