Article
Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation.
Stem cell reports - 14 Jul 2020
Ramdas Baskar, Mali Raghuveer Singh, Palam Lakshmi Reddy, Pandey Ruchi, Cai Zhigang, Pasupuleti Santhosh Kumar, Burns Sarah S, Kapur Reuben
Abstract excerpt
Studies of patients with acute myeloid leukemia (AML) have led to the identification of mutations that affect different cellular pathways. Some of these have been classified as preleukemic, and a stepwise evolution program whereby cells acquire additional mutations has been proposed in the development of AML. How the timing of acquisition of these mutations and their impact on transformation and the bone marrow...
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