Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

doi:10.1016/j.ccell.2015.03.009

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Article

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Cancer cell - 13 Apr 2015

Shih Alan H, Jiang Yanwen, Meydan Cem, Shank Kaitlyn, Pandey Suveg, Barreyro Laura, Antony-Debre Ileana, Viale Agnes, Socci Nicholas, Sun Yongming, Robertson Alexander, Cavatore Magali, de Stanchina Elisa, Hricik Todd, Rapaport Franck, Woods Brittany, Wei Chen, Hatlen Megan, Baljevic Muhamed, Nimer Stephen D, Tallman Martin, Paietta Elisabeth, Cimmino Luisa, Aifantis Iannis, Steidl Ulrich, Mason Chris, Melnick Ari, Levine Ross L

Abstract excerpt

Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice with mutations in Tet2 and Flt3, which resulted in fully penetrant, lethal AML. Multipotent Tet2(-/-);Flt3(ITD) progenitors (LSK CD48(+)CD150(-)) propagate disease in secondary recipients and were refractory to standard AML chemotherapy...

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Identifiers

PMID: 25873173
DOI: 10.1016/j.ccell.2015.03.009
PMCID: PMC4518555

Genes

FLT3
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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