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Article

Integrating Family-Based and Mendelian Randomization Designs.

Cold Spring Harbor perspectives in medicine - 1 Mar 2021

Hwang Liang-Dar, Davies Neil M, Warrington Nicole M, Evans David M

Abstract excerpt

Most Mendelian randomization (MR) studies published in the literature to date have involved analyses of unrelated, putatively independent sets of individuals. However, estimates obtained from these sorts of studies are subject to a range of biases including dynastic effects, assortative mating, residual population stratification, and horizontal pleiotropy. The inclusion of related individuals in MR studies can...

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Identifiers

PMID: 32122917
DOI: 10.1101/cshperspect.a039503
PMCID: PMC7919398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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