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Article

Family-based designs in the age of large-scale gene-association studies.

Nature reviews. Genetics - 1 May 2006

Laird Nan M, Lange Christoph

Abstract excerpt

Both population-based and family-based designs are commonly used in genetic association studies to locate genes that underlie complex diseases. The simplest version of the family-based design--the transmission disequilibrium test--is well known, but the numerous extensions that broaden its scope...

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PMID: 16619052
DOI: 10.1038/nrg1839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16619052-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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