Article
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.
Nature communications - 14 Jul 2020
Brumpton Ben, Sanderson Eleanor, Heilbron Karl, Hartwig Fernando Pires, Harrison Sean, Vie Gunnhild Åberge, Cho Yoonsu, Howe Laura D, Hughes Amanda, Boomsma Dorret I, Havdahl Alexandra, Hopper John, Neale Michael, Nivard Michel G, Pedersen Nancy L, Reynolds Chandra A, Tucker-Drob Elliot M, Grotzinger Andrew, Howe Laurence, Morris Tim, Li Shuai, Auton Adam, Windmeijer Frank, Chen Wei-Min, Bjørngaard Johan Håkon, Hveem Kristian, Willer Cristen, Evans David M, Kaprio Jaakko, Davey Smith George, Åsvold Bjørn Olav, Hemani Gibran, Davies Neil M
Abstract excerpt
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biases. We illustrate empirically how familial effects can affect estimates using data from 61,008 siblings from the...
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