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Article

Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion.

Frontiers in immunology - 1 Jan 2020

Alvarez Maite, Simonetta Federico, Baker Jeanette, Morrison Alyssa R, Wenokur Arielle S, Pierini Antonio, Berraondo Pedro, Negrin Robert S

Abstract excerpt

The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due to chronic stimulation. Targeting PD-1 has shown unprecedented clinical benefits for many cancers, which have been attributed to the prevention of immune suppression and exhaustion with enhanced anti-tumor...

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Identifiers

PMID: 32117218
DOI: 10.3389/fimmu.2020.00007
PMCID: PMC7026672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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