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Article

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma.

Oncotarget - 8 Nov 2016

Beldi-Ferchiou Asma, Lambert Marion, Dogniaux Stéphanie, Vély Frédéric, Vivier Eric, Olive Daniel, Dupuy Stéphanie, Levasseur Frank, Zucman David, Lebbé Céleste, Sène Damien, Hivroz Claire, Caillat-Zucman Sophie

Abstract excerpt

Programmed Death-1 (PD-1), an inhibitory receptor expressed by activated lymphocytes, is involved in regulating T- and B-cell responses. PD-1 and its ligands are exploited by a variety of cancers to facilitate tumor escape through PD-1-mediated functional exhaustion of effector T cells. Here, we report that PD-1 is upregulated on Natural Killer (NK) cells from patients with Kaposi sarcoma (KS). PD-1 was expressed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27662664
DOI: 10.18632/oncotarget.12150
PMCID: PMC5341956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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