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Article

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization.

The Journal of allergy and clinical immunology - 1 Jan 2017

Pesce Silvia, Greppi Marco, Tabellini Giovanna, Rampinelli Fabio, Parolini Silvia, Olive Daniel, Moretta Lorenzo, Moretta Alessandro, Marcenaro Emanuela

Abstract excerpt

BACKGROUND: Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune responses by delivering potent inhibitory signals to T cells on interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing to immune escape mechanisms. Therapeutic PD-1 blockade has been shown to mediate tumor eradication with impressive clinical results. Little is known about the...

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Identifiers

PMID: 27372564
DOI: 10.1016/j.jaci.2016.04.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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