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Article

Aldosterone-Producing Cell Clusters in Normal and Pathological States

1 Dec 2017

Abstract excerpt

Primary aldosteronism (PA) significantly increases the risk of cardiovascular complications, and early diagnosis and targeted treatment based on its pathophysiology is warranted. Next-generation sequencing (NGS) has revealed recurrent somatic mutations in aldosterone-driving genes in aldosterone-producing adenoma (APA). By applying CYP11B2 (aldosterone synthase) immunohistochemistry and NGS to adrenal glands from...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 29202494
DOI: 10.1055/s-0043-122394

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