Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

doi:10.1136/annrheumdis-2019-216233

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Article

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

Annals of the rheumatic diseases - 1 Apr 2020

Klück Viola, van Deuren Rosanne C, Cavalli Giulio, Shaukat Amara, Arts Peer, Cleophas Maartje C, Crișan Tania O, Tausche Anne-Kathrin, Riches Philip, Dalbeth Nicola, Stamp Lisa K, Hindmarsh Jennie Harré, Jansen Tim L Th A, Janssen Matthijs, Steehouwer Marloes, Lelieveld Stefan, van de Vorst Maartje, Gilissen Christian, Dagna Lorenzo, Van de Veerdonk Frank L, Eisenmesser Elan Z, Kim SooHyun, Merriman Tony R, Hoischen Alexander, Netea Mihai G, Dinarello Charles A, Joosten Leo Ab

Abstract excerpt

OBJECTIVE: Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation induced by monosodium urate crystals. Since IL-37 is a pivotal anti-inflammatory cytokine suppressing the activity of IL-1, we conducted genetic and functional studies aimed at elucidating the role of IL-37 in the pathogenesis and treatment of gout. METHODS: Variant identification was performed by DNA sequencing of all...

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PMID: 32114511
DOI: 10.1136/annrheumdis-2019-216233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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