Article
Common genetic heterogeneity of human interleukin-37 leads to functional variance.
Cellular & molecular immunology - 1 Sept 2017
Yan Jingjing, Zhang Yuling, Cheng Shimeng, Kang Bin, Peng Jinbiao, Zhang Xiaodan, Yuan Meichun, Chu Wenqi, Zhang Wen, Shen Jiayin, Zhang Shuye
Abstract excerpt
Interleukin-37 (IL-37) is an inhibitory member of the IL-1 family of cytokines. We previously found that balanced selection maintains common variations of the human IL37 gene. However, the functional consequences of this selection have yet to be validated. Here, using cells expressing exogenous IL-37 variants, including IL-37 Ref and IL-37 Var1 and Var2, we found that the three variants of IL-37 exhibited...
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