Article
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
Nature communications - 11 Sept 2018
Offenbacher Steven, Jiao Yizu, Kim Steven J, Marchesan Julie, Moss Kevin L, Jing Li, Divaris Kimon, Bencharit Sompop, Agler Cary S, Morelli Thiago, Zhang Shaoping, Sun Lu, Seaman William T, Cowley Dale, Barros Silvana P, Beck James D, Munz Matthias, Schaefer Arne S, North Kari E
Abstract excerpt
There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a GWAS for "high" gingival crevicular fluid IL-1β expression among 4910 European-American adults and identify association signals in the IL37 locus. rs3811046 at this locus (p = 3.3 × 10-22) is associated with severe chronic periodontitis (OR = 1.50; 95% CI = 1.12-2.00), 10-year incident tooth...
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