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Article

Mutational Load and the Functional Fraction of the Human Genome.

Genome biology and evolution - 1 Apr 2020

Galeota-Sprung Benjamin, Sniegowski Paul, Ewens Warren

Abstract excerpt

The fraction of the human genome that is functional is a question of both evolutionary and practical importance. Studies of sequence divergence have suggested that the functional fraction of the human genome is likely to be no more than ∼15%. In contrast, the ENCODE project, a systematic effort to map regions of transcription, transcription factor association, chromatin structure, and histone modification,...

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Identifiers

PMID: 32108234
DOI: 10.1093/gbe/evaa040
PMCID: PMC7151545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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