Article
Human deleterious mutation rate slows adaptation and implies high fitness variance
2023-09-04
Abstract excerpt
Each new human has an expected U d = 2-10 new deleterious mutations. Using a novel approach to capture complex linkage disequilibria from high U d using genome-wide simulations, we confirm that fitness decline due to the fixation of many slightly deleterious mutations can be compensated by rarer beneficial mutations of larger effect. The evolution of increased genome size and complexity have previously been attr...
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Identifiers and source
- Literature Corpus work
- fc4c8108-7d74-5afa-a1bb-88785d0440dc
- DOI
- 10.1101/2023.09.01.555871