Article

Non-identifiability and the Blessings of Misspecification in Models of Molecular Fitness

2022-01-30

Abstract excerpt

Understanding the consequences of mutation for molecular fitness and function is a fundamental problem in biology. Recently, generative probabilistic models have emerged as a powerful tool for estimating fitness from evolutionary sequence data, with accuracy sufficient to predict both laboratory measurements of function and disease risk in humans, and to design novel functional proteins. Existing techniques rest o...

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Literature Corpus work: dde5b375-877c-551c-a58b-da5666900e3d
DOI: 10.1101/2022.01.29.478324

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