Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.

Nature - 1 Mar 2020

Shao Zhengping, Flynn Ryan A, Crowe Jennifer L, Zhu Yimeng, Liang Jialiang, Jiang Wenxia, Aryan Fardin, Aoude Patrick, Bertozzi Carolyn R, Estes Verna M, Lee Brian J, Bhagat Govind, Zha Shan, Calo Eliezer

Abstract excerpt

The DNA-dependent protein kinase (DNA-PK), which comprises the KU heterodimer and a catalytic subunit (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor1. KU binds to DNA ends, initiates cNHEJ, and recruits and activates DNA-PKcs. KU also binds to RNA, but the relevance of this interaction in mammals is unclear. Here we use mouse models to show that DNA-PK has an unexpected role in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Ku Autoantigen

Share to Lymphoma

Share to Models, Animal

Share to RNA, Ribosomal, 18S

Share to RNA, Small Nucleolar

Source

Open in PubMed Open full text

Identifiers

PMID: 32103174
DOI: 10.1038/s41586-020-2041-2
PMCID: PMC10919329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.PMID 32103174Read ↗

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.Semantic proximity Read ↗

Noncanonical functions of Ku may underlie essentiality in human cellsSemantic proximity Read ↗

A pre-rRNA positive feedback loop drives malignant ribosome biogenesisSemantic proximity Read ↗

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic CellsSemantic proximity Read ↗

In-Depth Mapping of DNA-PKcs Signaling Uncovers Conserved Features of Its Kinase SpecificitySemantic proximity Read ↗

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.Semantic proximity Read ↗

The DNA‐dependent protein kinase: the director at the endSemantic proximity Read ↗

Structural insights into the role of DNA-PK as a master regulator in NHEJSemantic proximity Read ↗

DNA-PKcs suppresses illegitimate chromosome rearrangementsSemantic proximity Read ↗

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repairSemantic proximity Read ↗

Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.Semantic proximity Read ↗

DNA-PKcs Suppresses Illegitimate Chromosome RearrangementsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.