Article
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.
Nature communications - 25 Feb 2020
Essmann Clara L, Martinez-Martinez Daniel, Pryor Rosina, Leung Kit-Yi, Krishnan Kalaivani Bala, Lui Prudence Pokway, Greene Nicholas D E, Brown André E X, Pawar Vijay M, Srinivasan Mandayam A, Cabreiro Filipe
Abstract excerpt
Genetic and environmental factors are key drivers regulating organismal lifespan but how these impact healthspan is less well understood. Techniques capturing biomechanical properties of tissues on a nano-scale level are providing new insights into disease mechanisms. Here, we apply Atomic Force Microscopy (AFM) to quantitatively measure the change in biomechanical properties associated with ageing Caenorhabditis...
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