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Article

Ezh2 loss propagates hypermethylation at T cell differentiation–regulating genes to promote leukemic transformation

5 Aug 2018

Abstract excerpt

Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is a new pathological entity with poor outcomes in T cell ALL (T-ALL) that is characterized by a high incidence of loss-of-function mutations in polycomb repressive complex 2 (PRC2) genes. We generated a mouse model of ETP-ALL by deleting Ezh2, one of the PRC2 genes, in p53-null hematopoietic cells. The loss of Ezh2 in p53-null hematopoietic cells...

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PMID: 30080177
DOI: 10.1172/jci94645

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