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Article

A Powerful Pathway-Based Adaptive Test for Genetic Association with Common or Rare Variants.

American journal of human genetics - 2 Jul 2015

Pan Wei, Kwak Il-Youp, Wei Peng

Abstract excerpt

In spite of the success of genome-wide association studies (GWASs), only a small proportion of heritability for each complex trait has been explained by identified genetic variants, mainly SNPs. Likely reasons include genetic heterogeneity (i.e., multiple causal genetic variants) and small effect sizes of causal variants, for which pathway analysis has been proposed as a promising alternative to the standard...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26119817
DOI: 10.1016/j.ajhg.2015.05.018
PMCID: PMC4572508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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