Pathway analysis with next-generation sequencing data.

Abstract excerpt

Although pathway analysis methods have been developed and successfully applied to association studies of common variants, the statistical methods for pathway-based association analysis of rare variants have not been well developed. Many investigators observed highly inflated false-positive rates and low power in pathway-based tests of association of rare variants. The inflated false-positive rates and low...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Black or African American
• Share to Computer Simulation
• Share to Databases, Genetic