Article
Pathway-based approach using hierarchical components of collapsed rare variants.
Bioinformatics (Oxford, England) - 1 Sept 2016
Lee Sungyoung, Choi Sungkyoung, Kim Young Jin, Kim Bong-Jo, Hwang Heungsun, Park Taesung
Abstract excerpt
MOTIVATION: To address 'missing heritability' issue, many statistical methods for pathway-based analyses using rare variants have been proposed to analyze pathways individually. However, neglecting correlations between multiple pathways can result in misleading solutions, and pathway-based analyses of large-scale genetic datasets require massive computational burden. We propose a Pathway-based approach using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.