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Article

Pathway-based analysis for genome-wide association studies using supervised principal components.

Genetic epidemiology - 1 Nov 2010

Chen Xi, Wang Lily, Hu Bo, Guo Mingsheng, Barnard John, Zhu Xiaofeng

Abstract excerpt

Many complex diseases are influenced by genetic variations in multiple genes, each with only a small marginal effect on disease susceptibility. Pathway analysis, which identifies biological pathways associated with disease outcome, has become increasingly popular for genome-wide association studies (GWAS). In addition to combining weak signals from a number of SNPs in the same pathway, results from pathway...

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Identifiers

PMID: 20842628
DOI: 10.1002/gepi.20532
PMCID: PMC3480088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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