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Article

Pathway analysis of complex diseases for GWAS, extending to consider rare variants, multi-omics and interactions.

Biochimica et biophysica acta. General subjects - 1 Feb 2017

Kao Patrick Y P, Leung Kim Hung, Chan Lawrence W C, Yip Shea Ping, Yap Maurice K H

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) is a major method for studying the genetics of complex diseases. Finding all sequence variants to explain fully the aetiology of a disease is difficult because of their small effect sizes. To better explain disease mechanisms, pathway analysis is used to consolidate the effects of multiple variants, and hence increase the power of the study. While pathway...

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PMID: 27888147
DOI: 10.1016/j.bbagen.2016.11.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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