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Article

EpiMOGA: An Epistasis Detection Method Based on a Multi-Objective Genetic Algorithm.

Genes - 28 Jan 2021

Chen Yuanyuan, Xu Fengjiao, Pian Cong, Xu Mingmin, Kong Lingpeng, Fang Jingya, Li Zutan, Zhang Liangyun

Abstract excerpt

In genome-wide association studies, detecting high-order epistasis is important for analyzing the occurrence of complex human diseases and explaining missing heritability. However, there are various challenges in the actual high-order epistasis detection process due to the large amount of data, "small sample size problem", diversity of disease models, etc. This paper proposes a multi-objective genetic algorithm...

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Identifiers

PMID: 33525573
DOI: 10.3390/genes12020191
PMCID: PMC7911965

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