Article
Genetic studies of complex human diseases: characterizing SNP-disease associations using Bayesian networks.
BMC systems biology - 1 Jan 2012
Han Bing, Chen Xue-wen, Talebizadeh Zohreh, Xu Hua
Abstract excerpt
BACKGROUND: Detecting epistatic interactions plays a significant role in improving pathogenesis, prevention, diagnosis, and treatment of complex human diseases. Applying machine learning or statistical methods to epistatic interaction detection will encounter some common problems, e.g., very limited number of samples, an extremely high search space, a large number of false positives, and ways to measure the...
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