Article
KRAS mutations by digital PCR in circulating tumor cells isolated from the mesenteric vein are associated with residual disease and overall survival in resected colorectal cancer patients.
International journal of colorectal disease - 1 May 2020
Li Yan, Monzo Mariano, Moreno Isabel, Martinez-Rodenas Francisco, Hernandez Raquel, Castellano Joan J, Canals Jordi, Han Bing, Muñoz Carmen, Navarro Alfons
Abstract excerpt
PURPOSE: In colorectal cancer (CRC), circulating tumor cells (CTCs) are released into the mesenteric veins (MV). We chose to determine whether KRAS mutations detected in CTCs from blood obtained at the time of surgery could be a marker of survival. METHODS: From 52 surgically resected CRC patients who later relapsed, samples of tumor tissue, normal tissue, and blood from the peripheral vein (PV) and MV were...
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