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Article

Reliability of digital PCR in detecting KRAS mutation in colorectal cancer using plasma sample: A systematic review and meta-analysis.

Medicine - 10 Jul 2020

Ye Peng, Cai Peiling, Xie Jing, Zhang Jie

Abstract excerpt

BACKGROUND: Test on the KRAS somatic mutation status is necessary before cetuximab and panitumumab treatments are given to colorectal cancer patients. Metastatic colorectal cancer patients sometimes lack tumor tissue samples, and the testing of KRAS mutation in plasma samples requires highly sensitive methods. OBJECTIVES: The aim of this study was to evaluate the accuracy of digital PCR in detecting KRAS mutation...

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Identifiers

PMID: 32664155
DOI: 10.1097/MD.0000000000021171
PMCID: PMC7360253

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