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Article

KRAS G12V Mutation Detection by Droplet Digital PCR in Circulating Cell-Free DNA of Colorectal Cancer Patients.

International journal of molecular sciences - 1 Apr 2016

Olmedillas López Susana, García-Olmo Dolores C, García-Arranz Mariano, Guadalajara Héctor, Pastor Carlos, García-Olmo Damián

Abstract excerpt

KRAS mutations are responsible for resistance to anti-epidermal growth factor receptor (EGFR) therapy in colorectal cancer patients. These mutations sometimes appear once treatment has started. Detection of KRAS mutations in circulating cell-free DNA in plasma ("liquid biopsy") by droplet digital PCR (ddPCR) has emerged as a very sensitive and promising alternative to serial biopsies for disease monitoring. In...

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Source

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Identifiers

PMID: 27043547
DOI: 10.3390/ijms17040484
PMCID: PMC4848940

Genes

KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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