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Detection of KRAS Mutations Using Extracellular Vesicle DNA in Colorectal Cancer Patients

24 Mar 2025

Abstract excerpt

Liquid biopsy using circulating tumor DNA (ctDNA) is useful for precision medicine and molecular-guided oncology; however, its sensitivity is insufficient. We focused on DNA in extracellular vesicles (evDNA) as a new target for liquid biopsy and investigated its sensitivity. This observational study included 334 Stage I-IV colorectal cancer patients. evDNAs and ctDNAs were extracted from plasma collected before...

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PMID: 40129057
DOI: 10.1111/cas.70059

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