Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy.

doi:10.1158/1078-0432.CCR-14-0983

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Article

Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2015

Laurent-Puig Pierre, Pekin Deniz, Normand Corinne, Kotsopoulos Steve K, Nizard Philippe, Perez-Toralla Karla, Rowell Rachel, Olson Jeff, Srinivasan Preethi, Le Corre Delphine, Hor Thevy, El Harrak Zakaria, Li Xinyu, Link Darren R, Bouché Olivier, Emile Jean-François, Landi Bruno, Boige Valérie, Hutchison J Brian, Taly Valerie

Abstract excerpt

PURPOSE: KRAS mutations are predictive of nonresponse to anti-EGFR therapies in metastatic colorectal cancer (mCRC). However, only 50% of nonmutated patients benefit from them. KRAS-mutated subclonal populations nondetectable by conventional methods have been suggested as the cause of early progression. Molecular analysis technology with high sensitivity and precision is required to test this hypothesis....

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Identifiers

PMID: 25248381
DOI: 10.1158/1078-0432.CCR-14-0983

Genes

KRAS
EGFR
BRAF
NRAS

Provenance

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