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Article

Utility of KRAS mutation detection using circulating cell-free DNA from patients with colorectal cancer.

Cancer science - 1 Jul 2016

Yamada Takeshi, Iwai Takuma, Takahashi Goro, Kan Hayato, Koizumi Michihiro, Matsuda Akihisa, Shinji Seiichi, Yamagishi Aya, Yokoyama Yasuyuki, Tatsuguchi Atsushi, Kawagoe Tatsuro, Kitano Shiro, Nakayama Masato, Matsumoto Satoshi, Uchida Eiji

Abstract excerpt

In this study, we evaluated the clinical utility of detecting KRAS mutations in circulating cell-free (ccf)DNA of metastatic colorectal cancer patients. We prospectively recruited 94 metastatic colorectal cancer patients. Circulating cell-free DNA was extracted from plasma samples and analyzed for the presence of seven KRAS point mutations. Using the Invader Plus assay with peptide nucleic acid clamping method...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27116474
DOI: 10.1111/cas.12959
PMCID: PMC4946708

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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