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Article

KRAS genotypic changes of circulating tumor cells during treatment of patients with metastatic colorectal cancer.

PloS one - 1 Jan 2014

Kalikaki Aristea, Politaki Helen, Souglakos John, Apostolaki Stella, Papadimitraki Elisavet, Georgoulia Nefeli, Tzardi Maria, Mavroudis Dimitris, Georgoulias Vassilis, Voutsina Alexandra

Abstract excerpt

INTRODUCTION: Circulating tumor cells (CTCs) could represent a non-invasive source of cancer cells used for longitudinal monitoring of the tumoral mutation status throughout the course of the disease. The aims of the present study were to investigate the detection of KRAS mutations in CTCs from patients with metastatic colorectal cancer (mCRC) and to compare their mutation status during treatment or disease...

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Identifiers

PMID: 25137394
DOI: 10.1371/journal.pone.0104902
PMCID: PMC4138105

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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