Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced skeletal muscle growth in myostatin-deficient transgenic pigs had improved glucose uptake in stretozotocin-induced diabetes.

Transgenic research - 1 Apr 2020

Li Biao, Cui Wentao, Yang Jinzeng

Abstract excerpt

The size of skeletal muscle mass plays a significant role in glucose uptake in healthy and diabetic human subjects. Previously, we have generated myostatin-deficient (MSTN-/-) transgenic pigs via animal cloning technology. MSTN-/- pigs had dramatic phenotype with individual muscle mass increase by 100% over their wild-type controls, which provides a unique large animal model to investigate how enhanced skeletal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Insulin

Share to Muscle Development

Share to Muscle, Skeletal

Share to Myostatin

Source

Identifiers

PMID: 32078127
DOI: 10.1007/s11248-020-00194-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced skeletal muscle growth in myostatin-deficient transgenic pigs had improved glucose uptake in stretozotocin-induced diabetes.PMID 32078127Read ↗

Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs.Semantic proximity Read ↗

Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice.Semantic proximity Read ↗

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs.Semantic proximity Read ↗

Alterations in Adiposity and Glucose Homeostasis in Adult Gasp-1 Overexpressing Mice.Semantic proximity Read ↗

Functional verification of a porcine myostatin propeptide mutant.Semantic proximity Read ↗

Chronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs.Semantic proximity Read ↗

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System.Semantic proximity Read ↗

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscleSemantic proximity Read ↗

CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs.Semantic proximity Read ↗

Metabolic Functions of Myostatin and GDF11Semantic proximity Read ↗

Expression of myostatin pro domain results in muscular transgenic mice.Semantic proximity Read ↗

Swine Models of Type 2 Diabetes Mellitus: Insulin Resistance, Glucose Tolerance, and Cardiovascular ComplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.