Article
Functional verification of a porcine myostatin propeptide mutant.
Transgenic research - 1 Oct 2015
Ma Dezun, Jiang Shengwang, Gao Pengfei, Qian Lili, Wang Qingqing, Cai Chunbo, Xiao Gaojun, Yang Jinzeng, Cui Wentao
Abstract excerpt
Myostatin is a member of TGF-β superfamily that acts as a key negative regulator in development and growth of embryonic and postnatal muscles. In this study, the inhibitory activities of recombinant porcine myostatin propeptide and its mutated form (at the cleavage site of metalloproteinases of BMP-1/TLD family) against murine myostatin was evaluated in vivo by intraperitoneal injection into mice. Results showed...
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