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Article

Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs.

Oncotarget - 23 May 2017

Cai Chunbo, Qian Lili, Jiang Shengwang, Sun Youde, Wang Qingqing, Ma Dezun, Xiao Gaojun, Li Biao, Xie Shanshan, Gao Ting, Chen Yaoxing, Liu Jie, An Xiaorong, Cui Wentao, Li Kui

Abstract excerpt

Myostatin-deficient mice showed a remarkable hypertrophy of skeletal muscle, with a decreased fat mass and enhanced insulin sensitivity. Currently, it is unclear if the inhibition of myostatin could be used as an approach to treat human obesity and insulin resistance. In this study, we investigated if the inhibition of porcine myostatin has any effect on fat deposition and insulin sensitivity using genetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28432282
DOI: 10.18632/oncotarget.16822
PMCID: PMC5471021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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