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Article

Chronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs.

Frontiers in immunology - 1 Jan 2020

Giese Isabella-Maria, Schilloks Marie-Christin, Degroote Roxane L, Weigand Maria, Renner Simone, Wolf Eckhard, Hauck Stefanie M, Deeg Cornelia A

Abstract excerpt

People with diabetes mellitus have an increased risk for infections, however, there is still a critical gap in precise knowledge about altered immune mechanisms in this disease. Since diabetic INSC94Y transgenic pigs exhibit elevated blood glucose and a stable diabetic phenotype soon after birth, they provide a favorable model to explore functional alterations of immune cells in an early stage of diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33552065
DOI: 10.3389/fimmu.2020.607473
PMCID: PMC7862560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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